does it matter which gpu slot i use

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Rocket Yard > Industry News > Intel Introduces Thunderbolt 4: What Is It and Does It Matter? ... It’s been difficult to determine which OWC hardware uses more than one PCIe lane.

like the title says, when you are using only 2, out of 4, ram slots, which 2 are best? i prefer to use the 2 outer most ram slots to give the cpu heatsink fan more space for free airflow my MB instructions dont say much about it, so does it really matter if you use the different colored slots...